Endocrine Abstracts

Iodothyronine deiodinases are important enzymes for metabolism of thyroid hormones. These enzymes which are expressed in a variety of tissues are able to catalyze removal of iodine from thyroid hormones. Iodothyronine deiodinases I and II (DIO1 and DIO2) remove iodine from T4 to convert it to a more biologically active T3. The relative contribution of different tissue deiodinases to the establishment of a euthyroid state (proper production and concentration of T3) is not known...